Amlodipine Besylate

Basic Information

Place of Origin : India
Minimum Order Quantity : Negotiation
Price : Negotiation
Delivery Time : Negotiation
Payment Terms : D/P , D/A , B/L , T/T
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Supply Ability : Negotiation
COA : Available
  • Detail Information
  • Product Description

Amlodipine Besylate API

Cas No :

88150-42-9

Name :

Amlodipine Besylate

Synonyms :

(RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Molecular Formula :

C20H25ClN2O5

Melting Point :

199-201°C

Boiling Point :

527.2 °C

Molecular Weight :

408.879 g/mol

Density :

1.227g/cm3

Solubility :

Soluble in DMSO (20 mg/mL), water (10 mM), chloroform, ethanol (14 mg/mL), and methanol.

Uses :


  • Amlodipine is used alone or in combination with other medications to treat high blood pressure in adults and children 6 years and older. It is also used to treat certain types of angina (chest pain) and coronary artery disease (narrowing of the blood vessels that supply blood to the heart).

Amlodipine Besylate API

Amlodipine is considered a peripheral arterial vasodilator that exerts its action directly on vascular smooth muscle to lead to a reduction in peripheral vascular resistance, causing a decrease in blood pressure. Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the influx of calcium ions into both vascular smooth muscle and cardiac muscle. Experimental studies imply that amlodipine binds to both dihydropyridine and nondihydropyridine binding sites, located on cell membranes. The contraction of cardiac muscle and vascular smooth muscle are dependent on the movement of extracellular calcium ions into these cells by specific ion channels. Amlodipine blocks calcium ion influx across cell membranes with selectivity. A stronger effect of amlodipine is exerted on vascular smooth muscle cells than on cardiac muscle cells. Direct actions of amlodipine on vascular smooth muscle result in reduced blood pressure.

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