Colchicine

Basic Information

Place of Origin : India
Minimum Order Quantity : Negotiation
Price : Negotiation
Delivery Time : Negotiation
Payment Terms : D/P , D/A , B/L , T/T
Packaging Details : Your demand
Supply Ability : Negotiation
COA : Available
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  • Detail Information
  • Product Description

Colchicine API

Cas No :

64-86-8
Name :

Colchicine
Synonyms :

N-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
Molecular Formula :

C22H25NO6
Melting Point :

142-150 °C
Boiling Point :

726 °C
Molecular Weight :

399.437 g/mol
Density :

1.3±0.1 g/cm3
Solubility :

Soluble in DMSO (14mg/ml), 100% ethanol (7mg/ml), water (7mg/ml) or dimethylformamide (12mg/ml).

Uses :


  • Colchicine is used to prevent or treat attacks of gout (also called gouty arthritis). This condition is caused by too much uric acid in the blood. An attack of gout occurs when uric acid causes inflammation (pain, redness, swelling, and heat) in a joint.

Colchicine API

The exact mechanism of action of colchicine has not been fully established, however likely occurs via the downstream inhibition of inflammation caused by tubulin disruption.Studies have implied that that colchicine causes disruption of the inflammasome complex that is present in both monocytes and neutrophils, which normally leads to the activation of interleukin-1, an important mediator of inflammation. In addition to the above actions, colchicine acts to interfere with pathways including neutrophil adhesion and recruitment, superoxide production, the RhoA/Rho effector kinase (ROCK) pathway, as well as a type of nuclear factor κΒ (NF-κΒ) pathway, reducing inflammation.

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