Pregabalin

Basic Information

Place of Origin : India
Minimum Order Quantity : Negotiation
Price : Negotiation
Delivery Time : Negotiation
Payment Terms : D/P , D/A , B/L , T/T
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Supply Ability : Negotiation
COA : Available
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  • Detail Information
  • Product Description

Pregabalin API

Cas No :

148553-50-8
Name :

Pregabalin
Synonyms :

(3S)-3-(aminomethyl)-5-methylhexanoic acid
Molecular Formula :

C8H17NO2
Melting Point :

194-196°C
Boiling Point :

274 °C
Molecular Weight :

159.23 g/mol
Density :

0.997±0.06 g/cm3
Solubility :

Freely soluble in water and both basic and acidic solutions

Uses :


  • Pregabalin is used to treat epilepsy and anxiety. It's also taken to treat nerve pain. Nerve pain can be caused by different conditions including diabetes and shingles, or an injury. Pregabalin works in different ways: in epilepsy it stops seizures by reducing the abnormal electrical activity in the brain with nerve pain it blocks pain by affecting the pain messages travelling through the brain and down the spine in anxiety it stops your brain from releasing the chemicals that make you feel anxious

Pregabalin API

Although the mechanism of action has not been fully elucidated, studies involving structurally related drugs suggest that presynaptic binding of pregabalin to voltage-gated calcium channels is key to the antiseizure and antinociceptive effects observed in animal models. By binding presynaptically to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, pregabalin modulates the release of several excitatory neurotransmitters including glutamate, substance-P, norepinephrine, and calcitonin gene related peptide. In addition, pregabalin prevents the alpha2-delta subunit from being trafficked from the dorsal root ganglia to the spinal dorsal horn, which may also contribute to the mechanism of action. Although pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), it does not bind directly to GABA or benzodiazepine receptors

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